✉news ScienceBiology first seen 2 d ago, last 2 d ago, peak #10
Esketamine shifts microglia from inflammatory state in cell study
Original: Esketamine steers microglia away from inflammatory state via NMDAR2A in cell study
A laboratory cell study reports that esketamine, the antidepressant related to ketamine, appears to steer microglia — the brain's immune cells — away from an inflammatory state, acting through the NMDAR2A receptor. The finding, covered by science news outlet Bioengineer.org, may offer a clue to how the drug works beyond its known effects on depression symptoms.
Why now: New mechanistic insight into how a widely discussed antidepressant interacts with brain immune cells is drawing scientific attention.
Evidence
- Esketamine steers microglia away from inflammatory state via NMDAR2A in cell study · Bioengineer.org
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