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Study identifies DHODH as key target of QC6352 in glioblastoma

Original: DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

Research published in Nature reports that DHODH, an enzyme in the pyrimidine synthesis pathway, is the key target through which the KDM4 inhibitor QC6352 acts against glioblastoma stem cells. The finding suggests the compound's anti-tumour effects may stem from DHODH inhibition rather than KDM4 blockade alone, with potential implications for treating this aggressive brain cancer.

Why now: A new Nature paper offers a fresh therapeutic target for glioblastoma, a cancer with notoriously poor treatment options.

DHODHQC6352glioblastoma stem cellsNature

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Evidence

• DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells · Nature

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