✉news ScienceBiology first seen 1 d ago, last 9 h ago, peak #20

QC6352 found to target DHODH in glioblastoma stem cells

Original: DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

New research indicates that QC6352, developed as a KDM4 inhibitor, acts primarily on DHODH, an enzyme involved in pyrimidine synthesis, when attacking glioblastoma stem cells. The finding reshapes understanding of how the compound kills these treatment-resistant cells and could guide future drug design for an aggressive brain cancer with few effective options. Researchers and oncology watchers are weighing the implications for therapy development.

Why now: Fresh research reclassifies the mechanism of a candidate drug against a deadly brain cancer, drawing scientific attention.

QC6352DHODHKDM4glioblastomaNature

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• DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells · Nature

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