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Alzheimer's gene APOE4 may have a reversible weakness

Original: Alzheimer’s risk gene APOE4 may have a reversible weakness The Alzheimer’s risk gene APOE4 may actively damage brain blo

Researchers studying the APOE4 gene, the strongest genetic risk factor for Alzheimer's disease, report that it may actively damage brain blood vessels and disrupt the cellular systems that clear harmful proteins from the brain. In laboratory experiments, scientists were able to reverse some of these damaging effects, suggesting the gene's influence may not be permanent and could point toward new treatment strategies.

Why now: New research suggests the effects of the major Alzheimer's risk gene can be reversed, raising hopes for future therapies.

APOE4Alzheimer's disease

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Evidence

• Alzheimer’s risk gene APOE4 may have a reversible weakness The Alzheimer’s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in experiments, revealing… · ScienceScholar · 2

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