✉news ScienceBiology first seen 1 d ago, last 22 h ago, peak #21
Hot Spring Metagenome Reveals P450 Enzyme Captured With Oxygen Bound
Original: Hot Spring Metagenome Yields P450 Enzyme Frozen Mid-Breath With Oxygen on Board
Researchers report a cytochrome P450 enzyme recovered from a hot spring metagenome, crystallized or structurally resolved with oxygen bound at its active site — effectively frozen mid-reaction. The finding offers a rare direct view of how these heme enzymes activate oxygen, a step central to their role in metabolism and biocatalysis, and highlights hot spring microbial communities as a source of novel industrial enzymes.
Why now: Capturing an oxygen intermediate of a P450 enzyme is a rare structural feat of interest to biochemists and biotechnology researchers.
cytochrome P450hot spring metagenomeBioengineer.org
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