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Cancer stem cells found addicted to NAD molecule

Original: Some cancer cells aren't just hungry, they're addicted. 🔬 Researchers found that the stem cells driving high-risk MDS, a

Researchers report that stem cells driving high-risk myelodysplastic syndrome, an aggressive blood cancer, rely heavily on the molecule NAD for their energy supply. When the pathway that recycles NAD is blocked, the cancer stem cells run out of fuel and collapse. The findings point to a possible new treatment strategy targeting the metabolism of these hard-to-treat cells rather than the cancer more broadly.

Why now: The discovery of a metabolic weakness in aggressive blood cancer stem cells suggests a promising new drug target.

NADmyelodysplastic syndromecancer stem cells

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Evidence

• Some cancer cells aren't just hungry, they're addicted. 🔬 Researchers found that the stem cells driving high-risk MDS, an aggressive blood cancer, depend heavily on a molecule called NAD for energy. Block the pathway that recycles it, and the cancer stem cells hit an energy… · fusimotors · 3

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