Mmastodon ScienceScience first seen 1 d ago, last 1 d ago, peak #5
Study links ASPM mutations to disrupted brain stem cell development
Original: Online now: Microcephaly-causative ASPM mutations disrupt mitotic spindle orientation and timely specification of human
A new study published in Developmental Cell reports that ASPM mutations known to cause microcephaly disrupt mitotic spindle orientation and delay the specification of human outer radial glia cells. The finding offers mechanistic insight into how these genetic defects impair expansion of the neural progenitor population during cortical development, a key step in normal brain growth.
Why now: A newly published study sheds light on the cellular mechanism behind a genetic cause of microcephaly.
ASPMmicrocephalyouter radial glia cellsDevelopmental Cell
Evidence
- Online now: Microcephaly-causative ASPM mutations disrupt mitotic spindle orientation and timely specification of human outer radial glia cells https://www. cell.com/developmental-cell/fu lltext/S1534-5807(26)00393-X?rss=yes&utm_source=dlvr.it&utm_medium=mastodon # biology #… · DevelopmentalCell@mstdn.science · 1
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