Mmastodon ScienceBiology first seen 17 h ago, last 6 h ago, peak #5

Scientists Debate the Entourage Effect in Botanical Pharmacology

Original: Reductionist pharmacology spent decades attempting to isolate single active molecules, but biological systems evolved in

A growing discussion in biology circles argues that reductionist pharmacology spent decades trying to isolate single active molecules, while biological systems evolved as complex matrices. Proponents point to the botanical entourage effect, in which secondary terpenes modulate cannabinoid pharmacokinetics, altering receptor affinity and overall drug activity. The claim challenges the dominant single-molecule drug model and renews debate over whole-plant versus isolated-compound medicine.

Why now: Ongoing debate over whether whole-plant compounds work better than isolated molecules is drawing attention to cannabis and pharmacology research

cannabinoidsterpenespharmacology

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Evidence

• Reductionist pharmacology spent decades attempting to isolate single active molecules, but biological systems evolved in matrixes. The botanical entourage effect demonstrates that secondary terpenes modulate cannabinoid pharmacokinetics—altering receptor affinity and… · jilovecjoseph · 2

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