✉news ScienceBiology first seen 1 d ago, last 7 h ago, peak #14
Rewired protein decoding drives KRAS cancer growth and drug resistance
Original: Rewired decoding fuels KRAS-driven cancer growth and drug resistance
New research reported in Nature shows that rewired decoding, the process cells use to translate genetic instructions into proteins, fuels growth in KRAS-driven cancers and helps tumours resist targeted drugs. KRAS mutations are among the most common cancer drivers, so the findings may point to new treatment strategies that target translation itself to overcome resistance.
Why now: KRAS-driven cancers are common and hard to treat, so a newly identified resistance mechanism is scientifically and clinically significant.
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