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NFL Week 4 picks: Bills, Chiefs and Lions favored

Original: NFL Week 4 picks and predictions, straight-up and ATS: Bills bury Patriots, Chiefs and Lions roll

Week 4 of the NFL season is drawing predictions from analysts, with the Buffalo Bills expected to beat the New England Patriots convincingly, while the Kansas City Chiefs and Detroit Lions are also tipped to win comfortably. Predictions are offered both straight-up and against the spread, reflecting the weekly ritual of fans and handicappers sizing up matchups as the season takes shape.

Why now: Week 4 matchups are underway, prompting fans to seek picks and betting guidance.

Buffalo BillsNew England PatriotsKansas City ChiefsDetroit LionsNFL

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