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ADP-ribose found to trigger neuronal ferroptosis via ENT2

Original: ADP-ribose induces neuronal ferroptosis through ENT2-mediated nucleotide rewiring

Researchers report in Nature that ADP-ribose induces ferroptosis, an iron-dependent form of cell death, in neurons through rewiring of nucleotide metabolism mediated by the transporter ENT2. The finding links nucleotide transport to oxidative neuronal death and could point to new therapeutic angles for neurodegenerative conditions where ferroptosis is implicated.

Why now: A new Nature study reveals a previously unknown molecular mechanism of neuronal cell death, drawing attention from the biology community

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Evidence

• ADP-ribose induces neuronal ferroptosis through ENT2-mediated nucleotide rewiring · Nature

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