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Waddington's epigenetic landscape captivates biologists decades on

Original: C.H. Waddington's powerful image of embryonic stem cells specializing on a rolling landscape has captivated biologists s

British embryologist C.H. Waddington's 1950s metaphor of cells rolling down a landscape toward specialized fates remains a touchstone for biologists studying how embryonic stem cells choose their identity. New experimental data is now confirming his picture while also complicating it, prompting fresh discussion about how the classic model holds up against modern measurements of cell differentiation.

Why now: New experimental findings are testing Waddington's classic model of cell specialization, renewing interest in a decades-old idea.

C.H. Waddingtonembryonic stem cellsQuanta Magazine

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• C.H. Waddington's powerful image of embryonic stem cells specializing on a rolling landscape has captivated biologists since the 1950s. Experimental data is finally confirming, and complicating, his… # science # biology # genetics https://www. quantamagazine.org/how-does-li… · Econopass@flipboard.com · 2

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