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Salamanders and zebrafish regrow limbs by reactivating cellular repair program

Original: 🦎 NEW: # Salamanders and # zebrafish regrow lost limbs and fins by reactivating a cellular program after injury, forming

Researchers describe how salamanders and zebrafish regrow lost limbs and fins: after injury, the animals reactivate a cellular program that forms a blastema, a mass of cells that multiply and rebuild bone, nerve, muscle and blood vessels in the correct shape and size. Nerves are reported to drive the process, with the mechanism tied to evolutionary history, fueling discussion about what it could mean for human regenerative medicine.

Why now: The finding offers insight into natural regeneration that may one day inform regenerative therapies in humans.

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• 🦎 NEW: # Salamanders and # zebrafish regrow lost limbs and fins by reactivating a cellular program after injury, forming a blastema of cells that multiply and rebuild bone, nerve, muscle and blood vessels in the right shape and size. # Nerves drive the process, and # evolution… · tksst@fediscience.org · 9

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