human cells

A new study published in Nature presents a systematic mapping of functional signaling landscapes across the human phosphoproteome, charting how phosphorylation events regulate cell signalling on a large scale. The work offers researchers a resource for understanding cellular communication and how its disruption may contribute to disease. Reception details are limited so far.

Eric Topol, a prominent American physician-scientist, argues that aging in humans is driven substantially by the loss of cell identity: as cells age, they drift from their specialised roles, which undermines tissue function and contributes to age-related disease. Writing on his Ground Truths platform, he frames this cellular reprogramming as a central mechanism in the biology of aging, a topic of growing interest in longevity research.

Researchers have published a phosphoproteome atlas of human cell lines in Nature, charting the landscape of kinase activity across widely used laboratory models. The resource documents phosphorylation patterns that indicate which kinases are active in different cell lines, offering scientists a reference for studying cell signalling and for selecting appropriate models in cancer and drug research.