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- 1
A melanoma vaccine built on mRNA technology is being highlighted in medical news. The approach, similar to the technology used in some Covid-19 vaccines, is being studied as a way to train the immune system to recognize and attack melanoma cancer cells. If proven effective in trials, it could add a new personalized immunotherapy option for patients with advanced skin cancer.
- 2AstraZeneca invests $2bn in cancer drug partnership with Summit Therapeuticsβπ Astrazeneca invests $2bn in cancer drug tie-up Astrazeneca has invested $2bn in US pharmaceutical firm Summit Therapeu
AstraZeneca has invested $2bn in US biotech firm Summit Therapeutics as part of a major cancer research collaboration. The FTSE 100 drugmaker agreed to buy 109,000 shares in the Nasdaq-listed company at $18.36 per share, funding a tie-up aimed at developing new cancer treatments.
- 313-Year-Old Reported Cured of Deadly Brain Cancer DIPGβA 13-Year-Old Has Been Cured of DIPG, the Deadliest Childhood Brain Cancer
A 13-year-old has reportedly become the first patient cured of DIPG, an aggressive and almost universally fatal childhood brain cancer. The announcement, described as a world first, is drawing attention because DIPG has resisted decades of treatment efforts, with most children diagnosed surviving less than a year. If confirmed, it could mark a turning point in pediatric cancer research.
- 4CAR T cell therapy shows two years free of lupus flaresβTwo years later, CAR T cell therapy shows promise for life without lupus flares
Researchers at UMass Chan Medical School report that lupus patients treated with CAR T cell therapy have remained free of disease flares two years after receiving the one-time cell-based treatment. The therapy, originally developed for blood cancers, reprograms a patient's own immune cells, and the latest follow-up data suggest it may offer lasting remission in autoimmune disease.
- 5Study finds 485 pesticide chemicals linked to breast cancerβResearch finds 485 chemicals in US pesticide products linked to breast cancer
New research has identified 485 chemicals used in US pesticide products that are linked to breast cancer. The findings, reported by The Guardian, are raising concerns about consumer and worker exposure to common agricultural chemicals and prompting calls for tighter regulation and further safety review of pesticide ingredients.
- 6Researchers link cell crowding to optimal treatment timingβTreatment resistance is one of the key challenges in cancer and antibiotic therapy. Researchers led by Dr. Jona Kayser a
Researchers led by Dr. Jona Kayser at MPZPM report that physical processes in dense cell populations strongly influence the best timing of treatment cycles, with implications for both cancer therapy and antibiotics. Treatment resistance remains one of the central challenges in medicine, and the findings suggest that timing could be adjusted based on how tightly cells pack together rather than on biology alone. The work points to new ways of scheduling therapies to delay or avoid resistance.
- 7Missing Y chromosome pieces linked to cancer in menβΌStudy shows how missing pieces of Y chromosome drive cancer in men
A new study shows that loss of parts of the Y chromosome, a change seen in many men as they age, can actively drive cancer development. Researchers report the missing genetic material affects tumour growth in men, offering a possible explanation for why certain cancers behave differently between the sexes.
- 8Study Finds Proliferative Pause Could Help Prevent Brain MetastasisβΌProliferative Pause Reveals Window to Prevent Brain Metastasis
Researchers report that a 'proliferative pause' β a dormant phase cancer cells enter before spreading β may offer a critical window to intervene and stop brain metastasis before it takes hold. The findings, covered by Inside Precision Medicine, suggest targeting cells during this quiet period could prevent secondary brain tumours, a major cause of death in patients with advanced cancers such as breast cancer and melanoma.
- 9
New reporting highlights that people who survived cancer in childhood face a significantly elevated risk of serious mental health difficulties in adulthood, including depression, anxiety and other psychiatric conditions. The findings point to long-term psychological effects of early cancer diagnosis and treatment, and renew calls for survivors to receive sustained mental health monitoring and support, not just physical follow-up care, well into their adult lives.
- 10Theoretical physics sheds light on tumour DNA mechanismsβΌTheoretical physics helps unveil the molecular mechanisms of extra-chromosomal DNA in tumours
Researchers, working with Italy's National Institute for Nuclear Physics, have applied theoretical physics methods to uncover the molecular mechanisms of extra-chromosomal DNA in tumours. These DNA fragments exist outside normal chromosomes and are known to drive cancer growth and drug resistance. The study suggests physics-based modelling can reveal how such DNA behaves, opening new paths for understanding and potentially treating aggressive cancers.
- 11U.S. cancer diagnoses drop over holidays, outcomes worsenβΌU.S. cancer diagnoses drop, outcomes worse during holidays
UF Health researchers report that cancer diagnoses in the United States drop sharply during holiday periods, while outcomes for patients diagnosed around those dates are worse. The findings suggest holiday disruptions delay screenings and follow-up care, allowing cancers to be caught at later, harder-to-treat stages, and raise questions about how seasonal healthcare patterns affect patient survival.
- 12UConn Health Launches CAR-T Cell Therapy ProgramβΌUConn Health Launches Cutting-Edge CAR-T Cell Therapy Program
UConn Health has announced the launch of a new CAR-T cell therapy program, a form of immunotherapy that engineers a patient's own immune cells to fight cancer. The initiative brings an advanced, personalised cancer treatment to the Connecticut institution, expanding access for patients in the region who previously had to travel elsewhere for such therapy.
- 13Penn Medicine and IBA Launch Proton Therapy Joint VentureβΌPenn Medicine, IBA Form Joint Venture to Advance Proton Therapy, Radiation Oncology
Penn Medicine and Belgian medical technology company IBA have formed a joint venture aimed at advancing proton therapy and radiation oncology. The partnership will combine Penn Medicine's clinical expertise with IBA's technology to develop and expand proton therapy treatments for cancer patients.
- 14Experts hail 'secret DNA' find as potential key to cancer vaccineβ'Discovery of the century': Experts have found secret DNA that could unlock a cancer vaccine
Researchers describe the identification of previously overlooked DNA as a potential route toward a cancer vaccine, with some calling the finding a 'discovery of the century'. The work points to hidden genetic elements that could help the immune system recognise and attack tumours. Scientists say further research is needed before any vaccine can be developed, but the announcement has generated widespread attention.
- 15Study links Y chromosome loss and disruption to cancerβRecurrent deletions and regulatory disruption of the Y chromosome in cancer | Communications Biology
Researchers publishing in Communications Biology report that deletions and regulatory disruption of the Y chromosome recur across cancers, suggesting loss of this chromosome may play a functional role in tumour development rather than being a harmless byproduct. The findings add to growing interest in how sex chromosome instability shapes cancer risk and progression in men.
- 16
Susie Wiles, the White House chief of staff, has spoken publicly about her experience with breast cancer, saying the illness gave her a "deeper appreciation" for life. Her comments are drawing attention as she remains one of the most prominent figures in the Trump administration.
- 17New synthetic lethal drug targets microsatellite instability cancersβA synthetic lethal drug for microsatellite instability cancers
Researchers have reported the development of a synthetic lethal drug aimed at cancers with microsatellite instability, a genetic feature found in colorectal and other tumor types. Synthetic lethality exploits mutations unique to cancer cells, sparing healthy tissue. The work was published in Nature, and scientists say such drugs could expand treatment options for patients whose tumors resist existing immunotherapies.
- 18Everyday DNA damage reveals hidden weakness in some cancersβEveryday DNA damage reveals a hidden weakness in some cancers
Researchers at the Radcliffe Department of Medicine report that routine, everyday DNA damage can expose a hidden vulnerability in certain cancers. The finding suggests some tumours are less able to cope with constant low-level genetic wear, opening a potential route for targeted treatments that exploit this weakness.
- 19p53 shown to prevent chromothripsis by balancing transcription and replicationβp53 keeps a transcriptionβreplication balance that prevents chromothripsis
Research published in Nature reports that the p53 tumour suppressor protein maintains a balance between transcription and DNA replication, and that this balance prevents chromothripsis, a catastrophic form of chromosome shattering linked to cancer. The finding adds to understanding of how p53 suppresses tumours beyond its established roles in cell-cycle control and apoptosis, and highlights genome instability mechanisms relevant to cancer research.
- 20Boyle Introduces Legislation to Support Firefighter HealthβΌICYMI: Boyle Unveils New Legislation to Support Firefighter Health and Wellness
US Representative Brendan Boyle has unveiled new legislation aimed at supporting the health and wellness of firefighters. The bill, announced via his congressional office, focuses on addressing the physical and mental health needs of first responders. Details of the bill's provisions and co-sponsors have not yet been widely reported, but the announcement is drawing attention among those following firefighter welfare and congressional health policy.
- 21
Angela Stribling, a host known for her work on BET, has died following a battle with brain cancer. Details about her age, the date of her death, and her full career have not yet been widely reported. Viewers and colleagues are expected to share tributes to the longtime television personality as news of her death spreads.
- 22
New research suggests that analysing the biology of prostate cancer tumours can help doctors identify which patients are most likely to benefit from hormone therapy. The findings could support more personalised treatment decisions, allowing clinicians to target therapy at those most likely to respond rather than applying it universally. The report has drawn attention in medical news coverage.
- 23Building AI for Cancer Care in SomalilandβΌBuilding AI for Cancer Care in SomalilandBuilding AI for Cancer Care in Somaliland
A new initiative is exploring the use of artificial intelligence to improve cancer care in Somaliland, where diagnostic infrastructure and oncology services remain limited. The effort, highlighted in professional medical circles, focuses on adapting AI tools to local healthcare needs, aiming to support earlier detection and treatment decisions in a region with few specialists. It reflects a growing interest in applying AI to low-resource health systems.
- 24Physicists help explain how tumor DNA loops drive cancerβΌTheoretical physics helps uncover the molecular mechanisms of extrachromosomal DNA in tumors
Researchers at the University of Naples Federico II report that theoretical physics methods have helped reveal the molecular mechanisms governing extrachromosomal DNA in tumors. These circular DNA fragments, separate from chromosomes, are known to promote cancer growth and drug resistance. The study applies physical modelling to understand their behavior, potentially opening new avenues for cancer research and treatment strategies.
- 25Penn Medicine and IBA Launch Global Proton Therapy VentureβΌPenn Medicine and IBA Launch Joint Venture to Advance Proton Therapy and Radiation Oncology Program Development Worldwide
Penn Medicine and Belgian proton therapy company IBA have announced a joint venture to support the development of proton therapy and radiation oncology programs worldwide. The partnership aims to help hospitals and clinics internationally establish and expand advanced cancer treatment services, combining Penn Medicine's clinical expertise with IBA's technology. The announcement has been picked up by financial and international news outlets.
- 26Vyriad Launches First-in-Human Trial of CAR T Therapy VV169βΌVyriad Begins First-in-Human Trial of In Vivo CAR T Therapy VV169
Biotech company Vyriad has begun the first-in-human clinical trial of VV169, an in vivo CAR T therapy that engineers immune cells inside the patient's body rather than in a lab. The early-stage trial marks a first step in testing the safety of the experimental cancer treatment in people, an approach watched closely as it could simplify a cell therapy process that is currently complex and costly.
- 27Mount Sinai to test novel liquid radioembolic agent for brain tumorsβMount Sinai announces collaborative research agreement to evaluate novel liquid radioembolic agent for brain tumors
Mount Sinai has announced a collaborative research agreement to evaluate a novel liquid radioembolic agent for treating brain tumors. The therapy would deliver radiation directly to tumor tissue in liquid form, an approach being explored for cancers that are difficult to treat surgically. Details on the partner institution, trial design and timeline have not yet been released, and clinical results remain pending.
- 28American Cancer Society's Cancer Action Network takes its case to CongressβΌAmerican Cancer Societyβs Cancer Action Network visits Congress
Volunteers and advocates with the American Cancer Society's Cancer Action Network visited Capitol Hill to meet with members of Congress, urging support for cancer research funding and patient-focused legislation. The advocacy day brings grassroots concerns about prevention, treatment access, and federal research investment directly to lawmakers, and is part of the organization's ongoing effort to keep cancer policy on the national legislative agenda.
- 29
New figures from the European Commission show that 5% of Europeans consumed alcohol every day in 2025. The statistic highlights that despite overall declines in drinking across much of the continent, a small but notable share of the population still drinks daily, a pattern linked in public health research to higher risks of liver disease, cancer and other harms. Health advocates are likely to use the data in ongoing debates over alcohol pricing, advertising and labelling rules across EU member states.
- 30ALX Oncology publishes promising evorpacept gastric cancer trial data in Nature MedicineβΌALX Oncology Announces Nature Medicine Publication of ASPEN-06 Phase 2 Clinical Data Demonstrating Strong Responses and Durable Clinical Benefit with Evorpacept in HER2-Positive Gastric Cancer
ALX Oncology announced that Nature Medicine has published Phase 2 results from its ASPEN-06 trial, showing strong responses and durable clinical benefit with evorpacept combined with trastuzumab and chemotherapy in patients with HER2-positive gastric cancer. The publication adds peer-reviewed weight to the company's lead drug candidate and supports its ongoing development program in gastroesophageal cancers.
- 31Aeon essay argues for dropping the 'C-word' for cancerβDon't use the 'C-word' https://aeon.co/essays/we-need-a-better-way-to-describe-what-is-often-called-cancer # Science # H
An essay in Aeon argues that the word 'cancer' should be used far more cautiously, since the term lumps together conditions of wildly different danger and leads to overdiagnosis and overtreatment. The author calls for a better vocabulary to describe what is often called cancer, arguing that language shapes how patients understand risk and choose treatment.
- 32IBA and Penn Medicine Launch Noventra Oncology AllianceβIBA, Penn Medicine Announce Noventra Oncology Alliance Joint Venture
IBA and Penn Medicine have announced a joint venture called the Noventra Oncology Alliance, combining the particle therapy technology company's expertise with the academic medical center's clinical and research capabilities. The partnership is aimed at advancing cancer treatment, though further details about its scope, funding and first projects have not yet been made widely available.
- 33Y chromosome loss found recurrently disrupted in cancersβRecurrent deletions and regulatory disruption of the Y chromosome in cancer
Researchers have documented recurrent deletions and regulatory disruption of the Y chromosome across cancer types, according to a study published in Nature. The work suggests loss or alteration of Y chromosome genetic material may play a functional role in tumour development rather than being incidental, opening questions about how such changes influence cancer biology and potential sex-based differences in disease.
- 34
News coverage is highlighting lung cancer cases in people who have never smoked, a group historically overlooked in screening and public awareness. Reports note that never-smokers can develop the disease, often at later diagnosis, and discussion is focusing on possible causes such as air pollution, genetic factors, and radon exposure, as well as what this means for screening guidelines and research funding.
- 35Cancer vaccines emerge as promising new frontier in medicineβShe was ready to die. Now sheβs in remission β cancer vaccines could be the next big thing in medicine
A terminal cancer patient who had accepted she was dying is now in remission after receiving an experimental cancer vaccine. Doctors say the case highlights the growing potential of personalized cancer vaccines, which train the immune system to attack tumors. The story is fueling optimism that such vaccines could become a major new tool in cancer treatment.
- 36TTUHSC says Edison System destroys cancers without surgeryβTTUHSC 'Edison System' destroys certain cancers without surgery
Texas Tech University Health Sciences Center has announced the Edison System, a technology it says can destroy certain cancers without the need for surgery. The claim, reported by the Amarillo Globe-News, suggests a non-invasive alternative for treating selected tumors. Details on how the system works, which cancer types it targets, and whether clinical testing has begun have not been made available, so the announcement should be treated as an early claim pending independent confirmation.
- 37Aptadir raises β¬40M to advance demethylating medicinesβAptadir has β¬40M warchest to advance demethylating medicines
Spanish biotech Aptadir has secured a β¬40 million funding package to advance its demethylating medicines, a class of therapies targeting epigenetic changes in cancer cells. The company says the new capital will support development of its pipeline of epigenetic drug candidates as it moves toward clinical progress.
- 38
The Making Strides tribute garden has returned to Altoona, honoring those affected by breast cancer as part of the American Cancer Society's Making Strides Against Breast Cancer campaign. The garden serves as a tribute to survivors and those lost to the disease, and community members are being encouraged to visit and take part in the ongoing awareness efforts.