search
Werner helicase
Trends
- 1Phase 1 trial tests Werner helicase inhibitor for MSI tumors▼Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trial
A phase 1 clinical trial is investigating a Werner helicase inhibitor as a treatment for advanced microsatellite instability-high solid tumors. The early-stage study, published in Nature, aims to assess the drug's safety and dosing, and to gather preliminary evidence of whether blocking this DNA repair helicase can exploit the genetic instability of these tumors.