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Mendelian randomization
Trends
- 1Mendelian randomization takes center stage in the big data era●Mapping causal biology: Mendelian randomization in the era of big data
A new science release examines Mendelian randomization, a statistical method that uses genetic variation to establish causal links between risk factors and disease. Researchers argue that with massive biobank and genome datasets now available, the approach is becoming a central tool for mapping causal biology, while debates continue over its assumptions, limitations and potential for misuse.